The father of painter Nikiforos Lytras, Chatziantonis learnt the art of carving as an apprentice to Tinos marble artists. In 1839, he oversaw the construction of King Otto’s palace. In 1845, he produced the marble steps and floor in the courtyard of the Church of Evangelistria, Tinos, and in 1848 produced the marble phial of the church.
His sculpture is embedded within the Tinos folk tradition as handed down to him by his marble artist teachers.