Panos Sarafianos studied painting at the Athens School of Fine Arts in 1940-1945; in 1956-1959, he went on to conduct post-graduate studies in fresco and pottery at the Istituto d’Arte in Rome. Back to Greece, he worked as a painter at the Archaeological Museum in Athens and taught at the art workshop he had established for a number of years. His work is anthropocentric, both in its earliest phase of solidly-structured figures, and later, when expressionistic traits and an abstract tendency prevailed. In his experimentation, he sought to fuse contemporary pursuits with the study of the Greek and Italian Renaissance art.
His work has been exhibited in solo exhibitions in Greece. Sarafianos has also participated in group exhibitions in Greece and other countries.