He studied at the Athens School of Fine Arts from 1948 to 1954, at the Yannis Moralis studio. In 1957, on a scholarship from the State Scholarship Service, he went to Rome where he lived until 1960. From 1960 to 1970 he worked in Paris. At the invitation of D.A.A.D. he went to Berlin where he stayed from 1971 to 1972. From then until 1983 he divided his time between Athens and Paris, in 1984 settling permanently in Athens. From the beginning of the Sixties, when he started to exhibit, until today, his work has appeared in more than eighty solo exhibitions and he has participated in many group ones as well, in Greece and abroad, mainly in European cities. In 1986 he represented Greece at the Venice Biennale.

An artist fond of experimenting, Tsoclis has produced creations illustrating different directions and trends, combining painting with elements taken from outside painting, reality with the deceiving of the eye, art with technology, and he has also introduced video into his work.