He studied fine arts and architecture in Milan. Since 1954, he has lived in London and Florence. He has also lived in Cyprus and Greece.

The first show of his work took place in 1959 in Leicester Galleries, followed by numerous solo exhibitions in various European cities.
He has also participated in group exhibitions abroad, while in 1976 he represented Greece at the Venice Biennale along with Aglaia Lyberaki.

Michael Michaeledes’ painting initially focused on the human being and everyday life but since around 1959 he has gradually turned to abstract works, in which the artist explores light patterns. Since 1964, he has been regularly involved with relief. Using canvas on wood frame, he has produced a multitude of constructions which extend freely in space, animated by the interplay of light and shadow.