He studied sculpture at the Athens School of Fine Arts with Yannis Pappas (1962-1967) and theatre set design as well as interior design with Vassilis Vassiliadis. On Greek government scholarship, he concurrently studied folk art in northern Greece. He also studied painting at the University of Fresno, California (1967-1969), where he taught sculpture for a period of time. In 1970, he moved to Los Angeles, where he worked as set designer for the theatre, cinema and television.

Hs work has been presented in solo exhibitions in Greece and other countries; in 1990, a retrospective exhibition of his work was held at Zygos Gallery in Athens. He has also participated in group shows, including the exhibition “Los Angeles Artists” at the Los Angeles Museum (1971), the Sacramento Museum and San Francisco Museum Annual Exhibitions (1972), Panhellenic exhibitions in Athens, the Barcelona Biennale (1975) and the Romania Biennale (1985), the “World Miniature Sculpture” Exhibition in Budapest (1987) and “Modern Greek Sculpture” (Paris, 1992).

Starting with abstraction and abstract expressionism, Sotos Alexiou sought in his painting the illusionist depiction of volumes and three-dimensionality. This approach also applies in his sculpture, combining minimalist and constructivist influences. He has also been involved with happenings and collaborated with architects and urban planners in art gallery interior design.